Purpose: This study was undertaken to evaluate our 16-year experience with fistulas between the rectum and urethra or urinary bladder, collectively called recto-urinary fistulas (RUFs), and their devastating consequences in patients treated with radiation for prostate cancer.Methods: We downloaded the records of all patients with radiation-related
The chemistry of 1,3,4-thiadiazole is one of the most interesting scaffolds for synthesizing new drug molecules due to their numerous viseart etendu cashmerie pharmacological activities.Several modifications in the thiadiazole ring have been made, proving it to be more potent and highly effective with a less toxic scaffold for various biological ac
ABSTRACT Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2.The innate immune systems of these immensely abundant, anciently diverged mammals rema
Lateral habenula (LHb) neurons are activated by negative motivational stimuli and play key roles charger rt procharger in the pathophysiology of depression.Prior reports suggested that rostral entopeduncular nucleus (rEPN) neurons drive these responses in the LHb and rostromedial tegmental nucleus (RMTg), but these influences remain untested.Using
Abstract Background Health-related apps have great potential to enhance health and prevent disease globally, but their quality currently varies too much for clinicians to feel confident about recommending them to patients.The major quality concerns are dubious app content, loss of privacy associated with widespread sharing of the patient data they